发明授权
- 专利标题： Cyclic amine derivatives as EP4 receptor antagonists
- 专利标题（中）： 环胺衍生物作为EP4受体拮抗剂
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申请号： US14130451申请日： 2011-07-04
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公开(公告)号： US09181279B2公开(公告)日： 2015-11-10
- 发明人: Manuela Borriello , Sabrina Pucci , Luigi Piero Stasi , Lucio Rovati
- 申请人： Manuela Borriello , Sabrina Pucci , Luigi Piero Stasi , Lucio Rovati
- 申请人地址： IT Monza
- 专利权人： ROTTAPHARM BIOTECH S.R.L.
- 当前专利权人： ROTTAPHARM BIOTECH S.R.L.
- 当前专利权人地址： IT Monza
- 代理机构： Ohlandt Greeley Ruggiero & Perle L.L.P.
- 国际申请： PCT/EP2011/061226 WO 20110704
- 国际公布： WO2013/004290 WO 20130110
- 主分类号： C07D221/04
- IPC分类号： C07D221/04 ; C07D471/08 ; C07D211/34 ; C07D221/20 ; C07D401/06 ; C07F1/02 ; C07D207/16 ; C07D209/52 ; C07D209/54 ; C07D211/60 ; C07D453/06 ; C07F7/18 ; C07D205/04
摘要：
There is described a novel group of cyclic amine derivative compounds, having an EP4 receptor antagonistic activity and specifically pharmaceutical compounds which are useful for the treatment or alleviation of Prostaglandin E mediated diseases.The present invention therefore relates to novel compounds which are selective antagonists of the EP4 subtype of PGE2 receptors with analgesic and antinflammatory activity, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, inter alia for the treatment or alleviation of Prostaglandin E mediated diseases such as acute and chronic pain, osteoarthritis, inflammation-associated disorder as arthritis, rheumatoid arthritis, cancer, migraine and endometriosis.
公开/授权文献
- US20150087626A1 CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS 公开/授权日：2015-03-26
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