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    CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR AGONISTS
    1.
    发明申请
    CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR AGONISTS 有权
    循环胺衍生物作为EP4受体激动剂

    公开(公告)号：US20140243373A1

    公开(公告)日：2014-08-28

    申请号：US14127474

    申请日：2011-07-04

    申请人： Manuela Borriello ,  Sabrina Pucci ,  Luigi Piero Stasi ,  Lucio Rovati

    发明人： Manuela Borriello ,  Sabrina Pucci ,  Luigi Piero Stasi ,  Lucio Rovati

    IPC分类号： C07F1/02

    CPC分类号： C07F1/02 ,  C07D207/16 ,  C07D211/60

    摘要： There is described a group of novel cyclic amine derivative compounds having an EP4 receptor agonistic activity.Specifically, the compounds according to the invention are provided with analgesic, antinflammatory, antiglaucoma activity, and also with anti-osteoporosis and antiulcerative activity.The present invention therefore relates to novel cyclic amine derivative compounds, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, inter alia for the treatment or alleviation of Prostaglandin E mediated diseases such as pain, glaucoma, ulcerative colitis and osteoporosis.

    摘要翻译： 描述了一组具有EP4受体激动活性的新型环胺衍生物化合物。 具体地说，根据本发明的化合物具有镇痛，抗炎，抗青光眼活性，并具有抗骨质疏松和抗溃疡活性。 因此，本发明涉及新型环胺衍生物化合物，其制备方法，含有它们的药物组合物及其作为药物的用途，特别是用于治疗或缓解前列腺素E介导的疾病如疼痛，青光眼，溃疡性结肠炎和骨质疏松症。

    Cyclic amine derivatives as EP4 receptor agonists
    2.
    发明授权
    Cyclic amine derivatives as EP4 receptor agonists 有权
    环胺衍生物作为EP4受体激动剂

    公开(公告)号：US09120824B2

    公开(公告)日：2015-09-01

    申请号：US14127474

    申请日：2011-07-04

    申请人： Manuela Borriello ,  Sabrina Pucci ,  Luigi Piero Stasi ,  Lucio Rovati

    发明人： Manuela Borriello ,  Sabrina Pucci ,  Luigi Piero Stasi ,  Lucio Rovati

    IPC分类号： C07F1/02 ,  C07D207/16 ,  C07D211/60

    CPC分类号： C07F1/02 ,  C07D207/16 ,  C07D211/60

    摘要： There is described a group of novel cyclic amine derivative compounds having an EP4 receptor agonistic activity.Specifically, the compounds according to the invention are provided with analgesic, antinflammatory, antiglaucoma activity, and also with anti-osteoporosis and antiulcerative activity.The present invention therefore relates to novel cyclic amine derivative compounds, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, inter alia for the treatment or alleviation of Prostaglandin E mediated diseases such as pain, glaucoma, ulcerative colitis and osteoporosis.

    摘要翻译： 描述了一组具有EP4受体激动活性的新型环胺衍生物化合物。 具体地说，根据本发明的化合物具有镇痛，抗炎，抗青光眼活性，并具有抗骨质疏松和抗溃疡活性。 因此，本发明涉及新型环胺衍生物化合物，其制备方法，含有它们的药物组合物及其作为药物的用途，特别是用于治疗或缓解前列腺素E介导的疾病如疼痛，青光眼，溃疡性结肠炎和骨质疏松症。