A room pressure controlling system having a local exhaust valve, a supply air valve, a common exhaust air valve, controllers and a differential pressure sensor. The controller calculates a correction control output value for the valve operated as the room pressure controlling valve, which is either the supply air valve or the common exhaust air valve, based on a setting value and a room pressure measured by the differential pressure sensor. The controller evaluates whether or not the supply airflow rate and/or the exhaust airflow rate is changing, and if an airflow rate is changing, emphasizes rapid responsiveness of the room pressure control than a reduction in the frequency of actuation of the room pressure controlling valve, if the airflow rate is stable, the controller emphasizes the reduction in the frequency of actuation of the room pressure controlling valve than the rapid responsiveness of the room pressure control.