Various embodiments are generally directed to automatically observing reactions of viewers of 2D and 3D versions of the same visual content, and comparing aspects of those observations for indications of fatigue in the viewing of the 3D version. An apparatus includes a processor element; and logic to compare a first ROI (region of interest) data associated with a first viewer of a first visual presentation of a 2D (two-dimensional) version of visual content to a second ROI data associated with a second viewer of a second visual presentation of a 3D (three-dimensional) version of the visual content; and identify an instance of a statistically significant difference in a region of interest between the first ROI data and the second ROI data for at least one frame of the visual content indicative of an instance of viewing fatigue of the second viewer. Other embodiments are described and claimed.