发明授权
- 专利标题： Dual-acting benzoimidazole antihypertensive agents
- 专利标题（中）： 双效苯并咪唑抗高血压药
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申请号： US14132391申请日： 2013-12-18
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公开(公告)号： US09198899B2公开(公告)日： 2015-12-01
- 发明人: Paul Allegretti , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- 申请人： Paul Allegretti , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- 申请人地址： US CA South San Francisco
- 专利权人： Theravance Biopharma R&D IP, LLC
- 当前专利权人： Theravance Biopharma R&D IP, LLC
- 当前专利权人地址： US CA South San Francisco
- 代理商 Jeffrey A. Hagenah
- 主分类号： C07D235/08
- IPC分类号： C07D235/08 ; A61K31/4184 ; C07D401/12 ; C07D403/10 ; C07D403/12 ; C07D405/12 ; A61K31/4439 ; A61K31/5377 ; A61K45/06 ; C07D405/10
摘要：
The invention is directed to compounds having the formula: wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- US20140107120A1 DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS 公开/授权日：2014-04-17
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