- 专利标题： Real time monitoring and control of protein production processes using impedance spectroscopy
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申请号： US13315376申请日： 2011-12-09
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公开(公告)号： US09200031B2公开(公告)日： 2015-12-01
- 发明人: Cary N. Wauters , Alexander Zaydenberg
- 申请人： Cary N. Wauters , Alexander Zaydenberg
- 申请人地址： CH Opfikon US IL Bannockburn
- 专利权人： Baxalta GmbH,Baxalta Incorporated
- 当前专利权人： Baxalta GmbH,Baxalta Incorporated
- 当前专利权人地址： CH Opfikon US IL Bannockburn
- 代理机构： King & Spalding LLP
- 代理商 Kenneth H. Sonnenfeld; Margaret B. Brivanlou
- 主分类号： C07K1/30
- IPC分类号： C07K1/30 ; C07K1/34 ; G01N27/02 ; C07K1/24 ; G01R27/00
摘要：
Methods and systems for monitoring and/or controlling protein separation, purification, extraction, and/or fractionation processes are provided. The impedance of a protein mixture undergoing a protein process is measured and compared to a target reference impedance value or range of reference impedance values. If the measured impedance is not within an acceptable deviation of the target reference impedance value, a parameter of the protein mixture or process is adjusted.
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