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公开(公告)号：US09783792B2
公开(公告)日：2017-10-10
申请号：US12617578
申请日：2009-11-12
申请人： Alexander Zaydenberg , Susan Weber , Patrick Gavit , Laura Lei , Wolfgang Teschner , Harald A. Butterweck , Ursula Mais-Paul , Hans-Peter Schwarz
发明人： Alexander Zaydenberg , Susan Weber , Patrick Gavit , Laura Lei , Wolfgang Teschner , Harald A. Butterweck , Ursula Mais-Paul , Hans-Peter Schwarz
CPC分类号： C12N9/18
摘要： The present invention relates to purification of butyrylcholinesterase using anion exchange material, where the butyrylcholinesterase content is enriched at least 10 fold per total protein in the composition.
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2.发明授权公开(公告)号：US09643998B2
公开(公告)日：2017-05-09
申请号：US13315376
申请日：2011-12-09
CPC分类号： C07K1/30 , C07K1/24 , C07K1/303 , C07K1/34 , G01N27/021 , G01R27/00 , Y10T436/115831 , Y10T436/12 , Y10T436/25375
摘要： Methods and systems for monitoring and/or controlling protein separation, purification, extraction, and/or fractionation processes are provided. The impedance of a protein mixture undergoing a protein process is measured and compared to a target reference impedance value or range of reference impedance values. If the measured impedance is not within an acceptable deviation of the target reference impedance value, a parameter of the protein mixture or process is adjusted.
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3.发明授权公开(公告)号：US09200031B2
公开(公告)日：2015-12-01
申请号：US13315376
申请日：2011-12-09
摘要： Methods and systems for monitoring and/or controlling protein separation, purification, extraction, and/or fractionation processes are provided. The impedance of a protein mixture undergoing a protein process is measured and compared to a target reference impedance value or range of reference impedance values. If the measured impedance is not within an acceptable deviation of the target reference impedance value, a parameter of the protein mixture or process is adjusted.
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4.发明申请Real Time Monitoring and Control of Protein Production Processes Using Impedance Spectroscopy 有权使用阻抗光谱法实时监测和控制蛋白质生产过程公开(公告)号：US20120153221A1
公开(公告)日：2012-06-21
申请号：US13315376
申请日：2011-12-09
CPC分类号： C07K1/30 , C07K1/24 , C07K1/303 , C07K1/34 , G01N27/021 , G01R27/00 , Y10T436/115831 , Y10T436/12 , Y10T436/25375
摘要： Methods and systems for monitoring and/or controlling protein separation, purification, extraction, and/or fractionation processes are provided. The impedance of a protein mixture undergoing a protein process is measured and compared to a target reference impedance value or range of reference impedance values. If the measured impedance is not within an acceptable deviation of the target reference impedance value, a parameter of the protein mixture or process is adjusted.
摘要翻译： 提供了用于监测和/或控制蛋白质分离，纯化，提取和/或分馏过程的方法和系统。 测量经历蛋白质过程的蛋白质混合物的阻抗并将其与目标参考阻抗值或参考阻抗值的范围进行比较。 如果测量的阻抗不在目标参考阻抗值的可接受偏差范围内，则调整蛋白质混合物或过程的参数。
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公开(公告)号：US20100226907A1
公开(公告)日：2010-09-09
申请号：US12617578
申请日：2009-11-12
申请人： Alexander Zaydenberg , Susan Weber , Patrick Gavit , Laura Lei , Wolfgang Teschner , Harald A. Butterweck , Ursula Mais-Paul , Hans-Peter Schwarz
发明人： Alexander Zaydenberg , Susan Weber , Patrick Gavit , Laura Lei , Wolfgang Teschner , Harald A. Butterweck , Ursula Mais-Paul , Hans-Peter Schwarz
CPC分类号： C12N9/18
摘要： The present invention relates to purification of butyrylcholinesterase using anion exchange material, where the butyrylcholinesterase content is enriched at least 10 fold per total protein in the composition.
摘要翻译： 本发明涉及使用阴离子交换材料纯化丁酰胆碱酯酶，其中丁酰胆碱酯酶含量在组合物中富集至少10倍于总蛋白。
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