发明授权
US09200252B2 Compositions for inducing differentiation into retinal cells from retinal progenitor cells or inducing proliferation of retinal cells comprising Wnt signaling pathway activators
有权
用于诱导从视网膜祖细胞分化成视网膜细胞或诱导包含Wnt信号通路激活剂的视网膜细胞增殖的组合物
- 专利标题： Compositions for inducing differentiation into retinal cells from retinal progenitor cells or inducing proliferation of retinal cells comprising Wnt signaling pathway activators
- 专利标题（中）： 用于诱导从视网膜祖细胞分化成视网膜细胞或诱导包含Wnt信号通路激活剂的视网膜细胞增殖的组合物
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申请号： US13055708申请日： 2010-10-06
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公开(公告)号： US09200252B2公开(公告)日： 2015-12-01
- 发明人: Sung Sup Park , Ji Yeon Kim
- 申请人： Sung Sup Park , Ji Yeon Kim
- 申请人地址： KR Seoul
- 专利权人： SNU R&DB Foundation
- 当前专利权人： SNU R&DB Foundation
- 当前专利权人地址： KR Seoul
- 代理机构： Cooley LLP
- 优先权： KR10-2009-0094854 20091006; KR10-2009-0115389 20091126
- 国际申请： PCT/KR2010/006833 WO 20101006
- 国际公布： WO2011/043592 WO 20110414
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; C12N5/07 ; C12N5/0793 ; A61K35/12
摘要：
Disclosed is a composition for inducing the proliferation of retinal cells or the differentiation of retinal progenitor cells into retinal cells. The composition, similar to in vivo conditions for development during embryogenesis, induces stem cells to differentiate into a multitude of photoreceptor cells at high yield within a short period of time, without an additional gene transfer. In addition, the differentiated photoreceptor cells are useful in cellular therapy because they, when transplanted into degenerated or injured retinas, can be engrafted and fused within the retinas to prevent or cure retinal degeneration.
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