发明授权
US09206176B2 Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
有权
取代的N-（3-（嘧啶-4-基）苯基）丙烯酰胺类似物作为酪氨酸受体激酶BTK抑制剂
- 专利标题： Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
- 专利标题（中）： 取代的N-（3-（嘧啶-4-基）苯基）丙烯酰胺类似物作为酪氨酸受体激酶BTK抑制剂
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申请号： US14228184申请日： 2014-03-27
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公开(公告)号： US09206176B2公开(公告)日： 2015-12-08
- 发明人: David J. Bearss , Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , Sunil Sharma
- 申请人： University of Utah Research Foundation
- 申请人地址： US UT Salt Lake City
- 专利权人： University of Utah Research Foundation
- 当前专利权人： University of Utah Research Foundation
- 当前专利权人地址： US UT Salt Lake City
- 代理机构： Ballard Spahr LLP
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; A61K31/519 ; C07D239/42 ; C07D239/48 ; C07D487/04 ; C07D471/04 ; C07D239/30
摘要：
In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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