Invention Grant
- Patent Title: Utilization of pharmacological chaperones to improve manufacturing and purification of biologics
- Patent Title (中): 利用药物伴侣来改善生物制剂的制造和纯化
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Application No.: US12952036Application Date: 2010-11-22
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Publication No.: US09206457B2Publication Date: 2015-12-08
- Inventor: Hung V. Do
- Applicant: Hung V. Do
- Applicant Address: US NJ Cranbury
- Assignee: Amicus Therapeutics, Inc.
- Current Assignee: Amicus Therapeutics, Inc.
- Current Assignee Address: US NJ Cranbury
- Agency: Servilla Whitney LLC
- Main IPC: C12P21/02
- IPC: C12P21/02 ; C07D201/00 ; C12N5/07 ; C12N5/10 ; C12N9/00 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; A61K38/00 ; C07K1/14 ; C07K1/22
Abstract:
The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of the protein out of the cell's endoplasmic reticulum, and increase secretion of the protein by the cell.
Public/Granted literature
- US20110143419A1 Utilization of Pharmacological Chaperones to Improve Manufacturing and Purification of Biologics Public/Granted day:2011-06-16
Information query
