An engine having two or more fuel injectors is disclosed, where at least one of the injectors is used to port fuel inject fuel into the cylinder when the air intake valve is open. The open valve port fuel injector is used to inject a fuel that has alcohol as a constituent and is the same fuel injected by another fuel injector. In other embodiments, the open valve fuel injector is used to inject an anti-knock fuel containing alcohol while a primary fuel, is introduced by another injector. The operation of the open valve fuel injector can be optimized to maximize the vaporization cooling. In other embodiments, the open valve fuel injector may be used in conjunction with direct injection of the primary fuel or the anti-knock fuel. Heavy EGR can be optimally used with the various embodiments.