发明授权
- 专利标题: Drug condensation aerosols and kits
- 专利标题(中): 药物冷凝气溶胶和试剂盒
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申请号: US13569006申请日: 2012-08-07
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公开(公告)号: US09211382B2公开(公告)日: 2015-12-15
- 发明人: Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
- 申请人: Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
- 申请人地址: US CA Mountain View
- 专利权人: Alexza Pharmaceuticals, Inc.
- 当前专利权人: Alexza Pharmaceuticals, Inc.
- 当前专利权人地址: US CA Mountain View
- 代理机构: Swanson & Bratschun, L.L.C.
- 主分类号: A61K9/12
- IPC分类号: A61K9/12 ; A61K9/14 ; A61M15/00 ; H05B3/00 ; A61M11/04 ; A61K9/00 ; A61K31/4468 ; A61K31/519 ; A61K31/5415 ; A61K31/5517 ; A61K31/553
摘要:
The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided, wherein the device, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Methods for use are also disclosed.
公开/授权文献
- US20130032139A1 Drug Condensation Aerosols And Kits 公开/授权日:2013-02-07
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