发明授权
US09216159B2 Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages
有权
增加烯丙胺药物化合物用于局部治疗皮肤和皮肤附属物的真菌感染的有效性
- 专利标题: Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages
- 专利标题(中): 增加烯丙胺药物化合物用于局部治疗皮肤和皮肤附属物的真菌感染的有效性
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申请号: US14504766申请日: 2014-10-02
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公开(公告)号: US09216159B2公开(公告)日: 2015-12-22
- 发明人: Nardo Zaias , Pichit Suvanprakorn , Panida Vayumhasuwan
- 申请人: BIOPHILE CORPORATION, LTD.
- 申请人地址: TH
- 专利权人: BIOPHILE CORPORATION, LTD.
- 当前专利权人: BIOPHILE CORPORATION, LTD.
- 当前专利权人地址: TH
- 代理机构: Grimes & Yvon LLP
- 主分类号: A61K31/137
- IPC分类号: A61K31/137 ; A61K31/131 ; A61K9/127 ; A61K9/50 ; A61K47/10 ; A61K47/24 ; A61K47/26
摘要:
The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an acidic environment; the acidic environment altering the physiochemical properties of the active ingredient resulting in the active ingredient having a positive charge. The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages. The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle. The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.
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