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    Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages
    1.
    发明授权
    Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages 有权

    公开(公告)号：US10471024B2

    公开(公告)日：2019-11-12

    申请号：US15403412

    申请日：2017-01-11

    申请人： BIOPHILE CORPORATION, LTD.

    发明人： Nardo Zaias ,  Pichit Suvanprakorn ,  Panida Vayumhasuwan

    IPC分类号： A61K31/137 ,  A61K31/131 ,  A61K9/127 ,  A61K9/50 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26 ,  A61K9/00

    摘要： The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an acidic environment; the acidic environment altering the physiochemical properties of the active ingredient resulting in the active ingredient having a positive charge. The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages. The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle. The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.

    Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages
    2.
    发明授权
    Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages 有权
    增加烯丙胺药物化合物用于局部治疗皮肤和皮肤附属物的真菌感染的有效性

    公开(公告)号：US09216159B2

    公开(公告)日：2015-12-22

    申请号：US14504766

    申请日：2014-10-02

    申请人： BIOPHILE CORPORATION, LTD.

    发明人： Nardo Zaias ,  Pichit Suvanprakorn ,  Panida Vayumhasuwan

    IPC分类号： A61K31/137 ,  A61K31/131 ,  A61K9/127 ,  A61K9/50 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26

    CPC分类号： A61K31/137 ,  A61K9/0014 ,  A61K9/127 ,  A61K9/50 ,  A61K31/131 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26 ,  Y10S514/944 ,  Y10S514/946 ,  Y10S514/947 ,  Y10S514/975 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907

    摘要： The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an acidic environment; the acidic environment altering the physiochemical properties of the active ingredient resulting in the active ingredient having a positive charge. The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages. The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle. The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.

    摘要翻译： 本发明是用于局部治疗皮肤和皮肤附属物的真菌感染的烯丙胺药物化合物的有效性的增加。 烯丙胺活性成分在酸性环境中制备; 酸性环境改变活性成分的生理化学性质，导致活性成分具有正电荷。 配方中使用的正电荷和增强剂允许通过皮肤和皮肤附属物增加活性成分的渗透。 带正电的活性成分直接溶解在载体中或溶解在悬浮在载体中的多个珠粒中。 珠结构使带正电荷的活性成分和催化物质通过珠粒结构的分子扩散最小化，从而通过阻止带正电荷的活性成分与催化物质的相互作用来稳定珠粒内带正电荷的活性成分，从而延长 带正电荷的活性成分的保存期限。

    Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages
    4.
    发明授权
    Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages 有权
    增加烯丙胺药物化合物用于局部治疗皮肤和皮肤附属物的真菌感染的有效性

    公开(公告)号：US08052984B2

    公开(公告)日：2011-11-08

    申请号：US12012647

    申请日：2008-02-05

    申请人： Pichit Suvanprakorn ,  Panida Vayumhasuwan ,  Nardo Zaias

    发明人： Pichit Suvanprakorn ,  Panida Vayumhasuwan ,  Nardo Zaias

    IPC分类号： A61K31/137 ,  A61K31/685 ,  A61K47/24 ,  A61K9/00 ,  A61P31/10 ,  A61K8/02 ,  A61K8/41 ,  A61Q3/00 ,  A01N25/04 ,  A01N25/30 ,  A01N33/04

    CPC分类号： A61K31/137 ,  A61K9/0014 ,  A61K9/127 ,  A61K9/50 ,  A61K31/131 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26 ,  Y10S514/944 ,  Y10S514/946 ,  Y10S514/947 ,  Y10S514/975 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907

    摘要： The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an acidic environment; the acidic environment altering the physiochemical properties of the active ingredient resulting in the active ingredient having a positive charge. The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages. The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle. The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.

    摘要翻译： 本发明是用于局部治疗皮肤和皮肤附属物的真菌感染的烯丙胺药物化合物的有效性的增加。 烯丙胺活性成分在酸性环境中制备; 酸性环境改变活性成分的生理化学性质，导致活性成分具有正电荷。 配方中使用的正电荷和增强剂允许通过皮肤和皮肤附属物增加活性成分的渗透。 带正电的活性成分直接溶解在载体中或溶解在悬浮在载体中的多个珠子中。 珠结构使带正电荷的活性成分和催化物质通过珠粒结构的分子扩散最小化，从而通过阻止带正电荷的活性成分与催化物质的相互作用来稳定珠粒内的带正电荷的活性成分，从而延长 带正电荷的活性成分的保存期限。