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    Metabolic biomarkers for cognitive ability
    2.
    发明授权
    Metabolic biomarkers for cognitive ability 有权

    公开(公告)号：US11280797B2

    公开(公告)日：2022-03-22

    申请号：US16483260

    申请日：2018-02-02

    申请人： Georgetown University ,  University of Rochester

    发明人： Mark E. Mapstone ,  Howard J. Federoff ,  Massimo S. Fiandaca ,  Amrita K. Cheema

    IPC分类号： G01N33/68

    摘要： The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.

    Vaginal tissue rejuvenation compositions and methods
    7.
    发明授权
    Vaginal tissue rejuvenation compositions and methods 有权
    阴道组织复兴组成及方法

    公开(公告)号：US09375450B2

    公开(公告)日：2016-06-28

    申请号：US14239774

    申请日：2012-07-10

    申请人： Peter Takacs ,  Keith A. Candiotti ,  Carlos A. Medina

    发明人： Peter Takacs ,  Keith A. Candiotti ,  Carlos A. Medina

    IPC分类号： A61K33/30 ,  A61K31/426 ,  A61F6/08 ,  A61K31/192 ,  A61K31/20

    CPC分类号： A61K33/30 ,  A61F6/08 ,  A61K31/192 ,  A61K31/20 ,  A61K31/426 ,  A61K2300/00

    摘要： A method of stimulating elastin and/or collagen production in the tissues of the vagina, comprising the steps of providing a composition including at least one of a water soluble zinc salt such as zinc sulfate and a peroxisome proliferator-activated receptor beta/delta (PPAR β/δ) agonist, and administering the composition to the tissue of the vagina. Compositions for stimulating 5 elastin and/or collagen production in the tissues of the vagina are also disclosed.

    摘要翻译： 一种刺激所述阴道组织中的弹性蛋白和/或胶原产生的方法，包括以下步骤：提供包含水溶性锌盐如硫酸锌和过氧化物酶体增殖物激活受体β/δ（PPAR）中的至少一种的组合物 ＆bgr; /δ）激动剂，并将组合物施用于阴道的组织。 还公开了用于刺激阴道组织中的5种弹性蛋白和/或胶原产生的组合物。

    Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages
    9.
    发明授权
    Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages 有权
    增加烯丙胺药物化合物用于局部治疗皮肤和皮肤附属物的真菌感染的有效性

    公开(公告)号：US09216159B2

    公开(公告)日：2015-12-22

    申请号：US14504766

    申请日：2014-10-02

    申请人： BIOPHILE CORPORATION, LTD.

    发明人： Nardo Zaias ,  Pichit Suvanprakorn ,  Panida Vayumhasuwan

    IPC分类号： A61K31/137 ,  A61K31/131 ,  A61K9/127 ,  A61K9/50 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26

    CPC分类号： A61K31/137 ,  A61K9/0014 ,  A61K9/127 ,  A61K9/50 ,  A61K31/131 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26 ,  Y10S514/944 ,  Y10S514/946 ,  Y10S514/947 ,  Y10S514/975 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907

    摘要： The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an acidic environment; the acidic environment altering the physiochemical properties of the active ingredient resulting in the active ingredient having a positive charge. The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages. The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle. The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.

    摘要翻译： 本发明是用于局部治疗皮肤和皮肤附属物的真菌感染的烯丙胺药物化合物的有效性的增加。 烯丙胺活性成分在酸性环境中制备; 酸性环境改变活性成分的生理化学性质，导致活性成分具有正电荷。 配方中使用的正电荷和增强剂允许通过皮肤和皮肤附属物增加活性成分的渗透。 带正电的活性成分直接溶解在载体中或溶解在悬浮在载体中的多个珠粒中。 珠结构使带正电荷的活性成分和催化物质通过珠粒结构的分子扩散最小化，从而通过阻止带正电荷的活性成分与催化物质的相互作用来稳定珠粒内带正电荷的活性成分，从而延长 带正电荷的活性成分的保存期限。