发明授权
US09216983B2 Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
有权
具有选择性抗疟疾活性的二氢梭菌酸脱氢酶抑制剂
- 专利标题： Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
- 专利标题（中）： 具有选择性抗疟疾活性的二氢梭菌酸脱氢酶抑制剂
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申请号： US12339905申请日： 2008-12-19
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公开(公告)号： US09216983B2公开(公告)日： 2015-12-22
- 发明人: Margaret Phillips , Pradipsinh K. Rathod , Ramesh Gujjar , Alka Marwaha , Susan A. Charman
- 申请人： Margaret Phillips , Pradipsinh K. Rathod , Ramesh Gujjar , Alka Marwaha , Susan A. Charman
- 申请人地址： US TX Austin US WA Seattle AU Victoria
- 专利权人： BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM,UNIVERSITY OF WASHINGTON,MONASH UNIVERSITY
- 当前专利权人： BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM,UNIVERSITY OF WASHINGTON,MONASH UNIVERSITY
- 当前专利权人地址： US TX Austin US WA Seattle AU Victoria
- 代理机构： Saliwanchik, Lloyd & Eisenschenk
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D473/34 ; A61K31/519
摘要：
Compounds according to Formula I, Formula II, Formula III, Formula V, Formula VI, or to Formula VII, and pharmaceutical compositions of compounds that conform to Formula IV or Formula VIII: where R1 through R33 are prescribed, selectively inhibit P. falciparum dihydroorotate dehydrogenase. Accordingly, a method for preventing and treating malaria attaches to such compounds, as well as to pharmaceutically acceptable salts, solvates, stereoisomers, tautomers, and prodrugs thereof.