Invention Grant
US09216993B2 Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
有权
包含噻吩并嘧啶和噻吩并吡啶化合物的组合物及其使用方法
- Patent Title: Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
- Patent Title (中): 包含噻吩并嘧啶和噻吩并吡啶化合物的组合物及其使用方法
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Application No.: US14203233Application Date: 2014-03-10
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Publication No.: US09216993B2Publication Date: 2015-12-22
- Inventor: Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jay L. Hess , Duxin Sun , Xiaoqin Li
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones SC
- Agent David Staple
- Main IPC: C07D495/04
- IPC: C07D495/04 ; C07D495/16
Abstract:
The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 4: and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.
Public/Granted literature
- US20140275070A1 COMPOSITIONS COMPRISING THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF Public/Granted day:2014-09-18
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