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1.发明申请COMPOSITIONS COMPRISING THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF 有权包含三亚甲基嘧啶和三烯吡啶化合物的组合物及其使用方法公开(公告)号：US20140275070A1
公开(公告)日：2014-09-18
申请号：US14203233
申请日：2014-03-10
发明人： Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jay L. Hess , Duxin Sun , Xiaoqin Li
IPC分类号： C07D495/04 , C07D495/16
CPC分类号： C07D495/04 , C07D495/16 , C07D519/00
摘要： The present invention relates generally to thienopyrimidine and thienopyridine class compounds and methods of use thereof. In particular embodiments, the present invention provides compositions comprising thienopyrimidine class compounds and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins (e.g., for the treatment of leukemia, solid cancers and other diseases dependent on activity of MLL1 and MLL2 or menin).
摘要翻译： 本发明一般涉及噻吩并嘧啶和噻吩并吡啶类化合物及其使用方法。 在具体实施方案中，本发明提供包含噻吩并嘧啶类化合物的组合物和用于抑制menin与MLL1，MLL2和MLL-融合癌蛋白相互作用的方法（例如，用于治疗白血病，固体癌症和依赖于 MLL1和MLL2或menin）。
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2.发明授权公开(公告)号：US09505782B2
公开(公告)日：2016-11-29
申请号：US14937421
申请日：2015-11-10
发明人： Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jay L. Hess , Duxin Sun , Xiaoqin Li
IPC分类号： C07D495/04 , C07D495/16 , C07D519/00
CPC分类号： C07D495/04 , C07D495/16 , C07D519/00
摘要： The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 2: and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.
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3.发明授权Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof 有权包含噻吩并嘧啶和噻吩并吡啶化合物的组合物及其使用方法公开(公告)号：US09216993B2
公开(公告)日：2015-12-22
申请号：US14203233
申请日：2014-03-10
发明人： Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jay L. Hess , Duxin Sun , Xiaoqin Li
IPC分类号： C07D495/04 , C07D495/16
CPC分类号： C07D495/04 , C07D495/16 , C07D519/00
摘要： The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 4: and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.
摘要翻译： 本公开一般涉及噻吩并嘧啶和噻吩并吡啶化合物及其使用方法。 在具体实施方案中，本公开提供了包含式4的噻吩并嘧啶和噻吩并吡啶化合物的组合物：以及用于抑制menin与MLL1，MLL2和MLL-融合癌蛋白相互作用的方法。
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4.发明申请公开(公告)号：US20170253611A1
公开(公告)日：2017-09-07
申请号：US15296842
申请日：2016-10-18
发明人： Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jay L. Hess , Duxin Sun , Xiaoqin Li
IPC分类号： C07D495/04 , C07D495/16 , C07D519/00
CPC分类号： C07D495/04 , C07D495/16 , C07D519/00
摘要： The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 3: and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.
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5.发明授权公开(公告)号：US10160769B2
公开(公告)日：2018-12-25
申请号：US15296842
申请日：2016-10-18
发明人： Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jay L. Hess , Duxin Sun , Xiaoqin Li , Kevin Greenman , Mohamed Ibrahim , Artem Plekhov
IPC分类号： C07D495/04 , C07D495/16 , C07D519/00
摘要： The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 3: and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.
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6.发明申请COMPOSITIONS COMPRISING THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF 有权包含三亚甲基嘧啶和三烯吡啶化合物的组合物及其使用方法公开(公告)号：US20160137665A1
公开(公告)日：2016-05-19
申请号：US14937421
申请日：2015-11-10
发明人： Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jay L. Hess , Duxin Sun , Xiaoqin Li
IPC分类号： C07D495/04 , C07D519/00
CPC分类号： C07D495/04 , C07D495/16 , C07D519/00
摘要： The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 2: and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.
摘要翻译： 本公开一般涉及噻吩并嘧啶和噻吩并吡啶化合物及其使用方法。 在具体实施方案中，本公开提供了包含式2的噻吩并嘧啶和噻吩并吡啶化合物的组合物：以及用于抑制menin与MLL1，MLL2和MLL-融合癌蛋白相互作用的方法。
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