Invention Grant
- Patent Title: Cyclic amine substituted oxazolidinone CETP inhibitor
- Patent Title (中): 环胺取代的恶唑烷酮CETP抑制剂
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Application No.: US13881896Application Date: 2011-10-25
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Publication No.: US09221834B2Publication Date: 2015-12-29
- Inventor: Zhijian Lu , Yi-Heng Chen , Cameron Smith , Hong Li , Christopher F. Thompson , Julianne Hunt , Florida Kallashi , Ramzi Sweis , Peter Sinclair , Samantha E. Adamson , Guizhen Dong , Debra L. Ondeyka , Xiaoxia Qian , Wanying Sun , Petr Vachal , Kake Zhao
- Applicant: Zhijian Lu , Yi-Heng Chen , Cameron Smith , Hong Li , Christopher F. Thompson , Julianne Hunt , Florida Kallashi , Ramzi Sweis , Peter Sinclair , Samantha E. Adamson , Guizhen Dong , Debra L. Ondeyka , Xiaoxia Qian , Wanying Sun , Petr Vachal , Kake Zhao
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Eric A. Meade; Catherine D. Fitch
- International Application: PCT/US2011/057584 WO 20111025
- International Announcement: WO2012/058187 WO 20120503
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; A61K31/506 ; A61K31/5377 ; A61K31/4545 ; A61K31/497 ; A61K31/444 ; C07D491/08 ; C07D417/14 ; C07D413/14 ; A61K31/42 ; A61K45/06 ; C07D413/06
Abstract:
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A3 is a substituted phenyl group or indanyl group. Formula (I).
Public/Granted literature
- US20130331372A1 Cyclic Amine Substituted Oxazolidinone CETP Inhibitor Public/Granted day:2013-12-12
Information query
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