A pump system including a drive mechanism that provides a pumping force, a primary pump including a first pump cavity, an actuating element in reciprocal relation with the first pump cavity, and an outlet fluidly connected to a reservoir, a force translator that facilitates pump force transfer from the drive mechanism to the actuating element, a pressure regulation mechanism including a reciprocating pump that includes a pump chamber including an inlet manifold fluidly connected to the reservoir, a valve located within the inlet manifold, and a reciprocating element in reciprocal relation with the pump chamber. The pressure regulation mechanism preferably passively ceases force transfer from the drive mechanism to the primary pump based on the pressure of the reservoir.