Invention Grant
- Patent Title: Processes for producing NEP inhibitors or prodrugs thereof
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Application No.: US14715129Application Date: 2015-05-18
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Publication No.: US09227934B2Publication Date: 2016-01-05
- Inventor: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
- Applicant: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent David Kurlandsky
- Priority: EP08150353 20080117
- Main IPC: C07D207/38
- IPC: C07D207/38

Abstract:
The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
Public/Granted literature
- US20150246881A1 Processes Public/Granted day:2015-09-03
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