Invention Grant
US09227946B2 1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1a activity for the treatment of cognitive impairment
有权
1- [2-（2,4-二甲基苯基硫烷基） - 苯基]哌嗪作为具有组合的5-羟色胺再摄取的化合物，用于治疗认知障碍的5-HT3和5-HT1a活性
![1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1a activity for the treatment of cognitive impairment](/docs/US/2016-01-05/US09227946B2/abs.jpg.600x600.jpg)
- Patent Title: 1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1a activity for the treatment of cognitive impairment
- Patent Title (中): 1- [2-（2,4-二甲基苯基硫烷基） - 苯基]哌嗪作为具有组合的5-羟色胺再摄取的化合物，用于治疗认知障碍的5-HT3和5-HT1a活性
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Application No.: US14242337Application Date: 2014-04-01
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Publication No.: US09227946B2Publication Date: 2016-01-05
- Inventor: Andre Faldt , Rene Holm , Heidi Lopez de Diego
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Copenhagen-Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Copenhagen-Valby
- Agency: Fish & Richardson P.C.
- Priority: DK200600824 20060616; DK200601223 20060922; DK200601384 20061025; DK200700427 20070320
- Main IPC: A61K31/495
- IPC: A61K31/495 ; C07D295/096 ; A61K9/14
![1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1a activity for the treatment of cognitive impairment](/abs-image/US/2016/01/05/US09227946B2/abs.jpg.150x150.jpg)
Abstract:
1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.
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