公开(公告)号：US11279682B2

公开(公告)日：2022-03-22

申请号：US16294647

申请日：2019-03-06

Applicant: H. Lundbeck A/S

Inventor： Heidi Lopez de Diego ,  Kim Lasse Christensen ,  Rene Holm ,  Jens Kateb

IPC: C07D295/096 ,  C07D207/28

Abstract: The present invention provides vortioxetine pyroglutamate salt and pharmaceutical compositions comprising said salt.

公开(公告)号：US20200163959A1

公开(公告)日：2020-05-28

申请号：US16502677

申请日：2019-07-03

Applicant: H. Lundbeck A/S

Inventor： André Faldt ,  Heidi Lopez de Diego ,  Rene Holm

IPC: A61K31/495 ,  A61K9/14 ,  C07D295/096

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

公开(公告)号：US20180333408A1

公开(公告)日：2018-11-22

申请号：US15845677

申请日：2017-12-18

Applicant: H. Lundbeck A/S

Inventor： André Faldt ,  Heidi Lopez de Diego ,  Rene Holm

IPC: A61K31/495 ,  C07D295/096 ,  A61K9/14

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

公开(公告)号：US09227946B2

公开(公告)日：2016-01-05

申请号：US14242337

申请日：2014-04-01

Applicant: H. Lundbeck A/S

Inventor： Andre Faldt ,  Rene Holm ,  Heidi Lopez de Diego

IPC: A61K31/495 ,  C07D295/096 ,  A61K9/14

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

Abstract translation: 1- [2-（2,4-二甲基苯基硫烷基）苯基]哌嗪显示出对SERT，5-HT3和5-HT1A的有效活性，并且可以用于治疗认知障碍，特别是抑郁症患者。

公开(公告)号：US10287261B2

公开(公告)日：2019-05-14

申请号：US15152902

申请日：2016-05-12

Applicant: H. Lundbeck A/S

Inventor： Heidi Lopez de Diego ,  Kim Lasse Christensen ,  Rene Holm ,  Jens Kateb

IPC: C07D295/096 ,  A61P25/00 ,  A61K31/495 ,  C07D207/28

Abstract: The present invention provides vortioxetine pyroglutamate salt and pharmaceutical compositions comprising said salt.

公开(公告)号：US09125909B2

公开(公告)日：2015-09-08

申请号：US14326725

申请日：2014-07-09

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Andre Faldt ,  Arne Mork ,  Heidi Lopez de Diego ,  Rene Holm ,  Tine Bryan Stensbol

IPC: A61K31/495 ,  C07D295/096

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: This disclosure relates to 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or a pharmaceutically acceptable salt thereof in a crystalline form.

Abstract translation: 本公开涉及结晶形式的1- [2-（2,4-二甲基苯基硫烷基） - 苯基]哌嗪或其药学上可接受的盐。

公开(公告)号：US11458134B2

公开(公告)日：2022-10-04

申请号：US16502677

申请日：2019-07-03

Applicant: H. Lundbeck A/S

Inventor： André Faldt ,  Heidi Lopez de Diego ,  Rene Holm ,  Michael J. Mealy

IPC: A61K31/495 ,  C07D295/096 ,  A61K9/14 ,  A61P25/22

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

公开(公告)号：US09861630B1

公开(公告)日：2018-01-09

申请号：US15674043

申请日：2017-08-10

Applicant: H. Lundbeck A/S

Inventor： André Faldt ,  Heidi Lopez de Diego ,  Rene Holm

IPC: A61K31/495 ,  C07D295/096 ,  A61K9/14

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl)]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

公开(公告)号：US20160368884A1

公开(公告)日：2016-12-22

申请号：US15152902

申请日：2016-05-12

Applicant: H. Lundbeck A/S

Inventor： Heidi Lopez de Diego ,  Kim Lasse Christensen ,  Rene Holm ,  Jens Kateb

IPC: C07D295/096 ,  C07D207/28

CPC classification number: C07D295/096 ,  C07D207/28

Abstract: The present invention provides vortioxetine pyroglutamate salt and pharmaceutical compositions comprising said salt.

Abstract translation: 本发明提供了含有所述盐的伏妥妥汀焦谷氨酸盐和药物组合物。

公开(公告)号：US20140315921A1

公开(公告)日：2014-10-23

申请号：US14326725

申请日：2014-07-09

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Andre Faldt ,  Arne Mork ,  Heidi Lopez de Diego ,  Rene Holm ,  Tine Bryan Stensbol ,  Nicholas Moore

IPC: C07D295/096

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: This disclosure relates to 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or a pharmaceutically acceptable salt thereof in a crystalline form.

Abstract translation: 本公开涉及结晶形式的1- [2-（2,4-二甲基苯基硫烷基） - 苯基]哌嗪或其药学上可接受的盐。