Invention Grant
US09249190B2 Method of suppressing gene transcription through histone lysine methylation
有权
通过组蛋白赖氨酸甲基化抑制基因转录的方法
- Patent Title: Method of suppressing gene transcription through histone lysine methylation
- Patent Title (中): 通过组蛋白赖氨酸甲基化抑制基因转录的方法
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Application No.: US12896510Application Date: 2010-10-01
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Publication No.: US09249190B2Publication Date: 2016-02-02
- Inventor: Ming-ming Zhou , Shiraz Mujtaba
- Applicant: Ming-ming Zhou , Shiraz Mujtaba
- Applicant Address: US NY New York
- Assignee: MOUNT SINAI SCHOOL OF MEDICINE
- Current Assignee: MOUNT SINAI SCHOOL OF MEDICINE
- Current Assignee Address: US NY New York
- Agency: Baker Botts L.L.P.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/005 ; C12N9/10 ; A61K48/00
Abstract:
The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine methyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3-K27) thereby suppressing the transcription of the gene.
Public/Granted literature
- US20110123511A1 Method of Suppressing Gene Transcription Through Histone Lysine Methylation Public/Granted day:2011-05-26
Information query
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