发明授权
US09249231B2 Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif
有权
与特异性结合切割的半胱天冬酶基序的母体特异性和上下文相关抗体
- 专利标题： Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif
- 专利标题（中）： 与特异性结合切割的半胱天冬酶基序的母体特异性和上下文相关抗体
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申请号： US13289651申请日： 2011-11-04
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公开(公告)号： US09249231B2公开(公告)日： 2016-02-02
- 发明人: Michael Comb , Ailan Guo , John Edward Rush, II , Jun-Ming Cai , Jing Li , Jing Zhou
- 申请人： Michael Comb , Ailan Guo , John Edward Rush, II , Jun-Ming Cai , Jing Li , Jing Zhou
- 申请人地址： US MA Danvers
- 专利权人： Cell Signaling Technology, Inc.
- 当前专利权人： Cell Signaling Technology, Inc.
- 当前专利权人地址： US MA Danvers
- 主分类号： C07K16/44
- IPC分类号： C07K16/44 ; C07K16/00 ; C12N5/07
摘要：
There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.
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