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    Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif
    3.
    发明授权
    Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif 有权
    与特异性结合切割的半胱天冬酶基序的母体特异性和上下文相关抗体

    公开(公告)号：US09249231B2

    公开(公告)日：2016-02-02

    申请号：US13289651

    申请日：2011-11-04

    申请人： Michael Comb ,  Ailan Guo ,  John Edward Rush, II ,  Jun-Ming Cai ,  Jing Li ,  Jing Zhou

    发明人： Michael Comb ,  Ailan Guo ,  John Edward Rush, II ,  Jun-Ming Cai ,  Jing Li ,  Jing Zhou

    IPC分类号： C07K16/44 ,  C07K16/00 ,  C12N5/07

    CPC分类号： C07K16/18 ,  C07K16/44 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/33 ,  C07K2317/34

    摘要： There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.

    摘要翻译： 提供了一种特异性基因，独立于上下文的抗体，其特异性结合由（i）至少一个sumoylated赖氨酸残基组成的复发性修饰基序，和（ii）通过肽键与所述sumoylated结合的一个或多个简并氨基酸 赖氨酸残基，所述抗体特异性结合所述基序在其再次发生的生物体内的多个非同源肽或蛋白质中。 还提供了一种特异性基因，独立于上下文的抗体，其特异性结合由（i）C末端天冬氨酸残基组成的重复修饰基序，和（ii）一个或多个与肽键结合的简并氨基酸与所述 C末端天冬氨酸残基，所述抗体特异性结合所述基序在其再次发生的生物体内的多个非同源肽或蛋白质中。

    Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Cleaved Caspase Motif or a Sumoylated Lysine-Containing Motif
    4.
    发明申请
    Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Cleaved Caspase Motif or a Sumoylated Lysine-Containing Motif 有权
    特异性和上下文独立的抗体，其特异性结合到切割的半胱天冬酶母体或含有Sumoylated赖氨酸的基序

    公开(公告)号：US20120208985A1

    公开(公告)日：2012-08-16

    申请号：US13289651

    申请日：2011-11-04

    申请人： Michael Comb ,  Ailan Guo ,  John Edward Rush, II ,  Jun-Ming Cai ,  Jing Li ,  Jing Zhou

    发明人： Michael Comb ,  Ailan Guo ,  John Edward Rush, II ,  Jun-Ming Cai ,  Jing Li ,  Jing Zhou

    IPC分类号： C07K16/00

    CPC分类号： C07K16/18 ,  C07K16/44 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/33 ,  C07K2317/34

    摘要： There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.

    摘要翻译： 提供了一种特异性基因，独立于上下文的抗体，其特异性结合由（i）至少一个sumoylated赖氨酸残基组成的复发性修饰基序，和（ii）通过肽键与所述sumoylated结合的一个或多个简并氨基酸 赖氨酸残基，所述抗体特异性结合所述基序在其再次发生的生物体内的多个非同源肽或蛋白质中。 还提供了一种特异性基因，独立于上下文的抗体，其特异性结合由（i）C末端天冬氨酸残基组成的重复修饰基序，和（ii）一个或多个与肽键结合的简并氨基酸与所述 C末端天冬氨酸残基，所述抗体特异性结合所述基序在复制的生物体内的多个非同源肽或蛋白质。