An asymmetrical hub bearing assembly for the wheel of a motor vehicle provides a flanged hub rotatable around an axis of rotation (x), a flange transversal to the axis (x), an outer ring with raceways axially spaced from one another, and two rows of balls, of which the axially outer row has a pitch circle with a diameter greater than that of the axially inner row. The flanged hub includes a tubular portion which protrudes in the axially outer direction beyond the flange and provides a thread for a single central threaded fastener adapted to releasably lock a wheel on the hub.