Invention Grant
- Patent Title: Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
- Patent Title (中): 四环杂环化合物及其用于治疗病毒性疾病的方法
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Application No.: US14343450Application Date: 2012-08-20
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Publication No.: US09265773B2Publication Date: 2016-02-23
- Inventor: Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Shuwen He , Xing Dai , Hong Liu , Zhong Lai , Clare London , Dong Xiao , Nicolas Zorn , Ravi Nargund
- Applicant: Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Shuwen He , Xing Dai , Hong Liu , Zhong Lai , Clare London , Dong Xiao , Nicolas Zorn , Ravi Nargund
- Applicant Address: US NJ Rahway IT Rome
- Assignee: Merck Sharp & Dohme Corp.,MSD Italia S.R.L.
- Current Assignee: Merck Sharp & Dohme Corp.,MSD Italia S.R.L.
- Current Assignee Address: US NJ Rahway IT Rome
- Agent Alysia A. Finnegan; Anna L. Cocuzzo
- Priority: WOPCT/CN2011/079465 20110908
- International Application: PCT/CN2012/001117 WO 20120820
- International Announcement: WO2013/033971 WO 20130314
- Main IPC: A61K31/553
- IPC: A61K31/553 ; C07D491/052 ; A61K31/519 ; A61K31/407 ; C07D498/22 ; A61K31/437 ; C07D491/147 ; C07D498/14 ; C07D498/04 ; A61K31/5365 ; A61K45/06
Abstract:
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
Public/Granted literature
- US20140213571A1 TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES Public/Granted day:2014-07-31
Information query
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