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1.发明授权Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases 有权四环杂环化合物及其用于治疗病毒性疾病的方法公开(公告)号：US09265773B2
公开(公告)日：2016-02-23
申请号：US14343450
申请日：2012-08-20
申请人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Shuwen He , Xing Dai , Hong Liu , Zhong Lai , Clare London , Dong Xiao , Nicolas Zorn , Ravi Nargund
发明人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Shuwen He , Xing Dai , Hong Liu , Zhong Lai , Clare London , Dong Xiao , Nicolas Zorn , Ravi Nargund
IPC分类号： A61K31/553 , C07D491/052 , A61K31/519 , A61K31/407 , C07D498/22 , A61K31/437 , C07D491/147 , C07D498/14 , C07D498/04 , A61K31/5365 , A61K45/06
CPC分类号： A61K31/553 , A61K31/407 , A61K31/437 , A61K31/519 , A61K31/5365 , A61K45/06 , C07D491/052 , C07D491/147 , C07D498/04 , C07D498/14 , C07D498/22 , Y02A50/387 , Y02A50/389 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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公开(公告)号：US07662809B2
公开(公告)日：2010-02-16
申请号：US11666583
申请日：2005-10-25
申请人： Caterina Ercolani , Joerg Habermann , Frank Narjes , Simona Ponzi , Michael Rowley , Ian Stansfield
发明人： Caterina Ercolani , Joerg Habermann , Frank Narjes , Simona Ponzi , Michael Rowley , Ian Stansfield
IPC分类号： C07D223/18 , A61K31/407
CPC分类号： C07D245/04 , C07D267/22 , C07D487/04 , C07D491/14 , C07D495/14
摘要： The present invention relates to tetracyclic indole compounds of formula (I); wherein R1, R2, R14, R15, A, Ar, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
摘要翻译： 本发明涉及式（I）的四环吲哚化合物; 其中R1，R2，R14，R15，A，Ar，Y和Z如本文所定义，及其药学上可接受的盐，包含它们的药物组合物及其用于治疗或预防丙型肝炎病毒感染的用途。
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3.发明授权Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases 有权嘧啶-4,6-二羧酸二酰胺，用于选择性抑制胶原酶公开(公告)号：US07166609B2
公开(公告)日：2007-01-23
申请号：US10700273
申请日：2003-11-03
申请人： Otmar Klingler , Reinhard Kirsch , Joerg Habermann , Klaus-Ulrich Weithmann , Christian Engel , Bernard Pirard
发明人： Otmar Klingler , Reinhard Kirsch , Joerg Habermann , Klaus-Ulrich Weithmann , Christian Engel , Bernard Pirard
IPC分类号： C07D239/54 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , A61K31/506 , A61P19/02
CPC分类号： C07D239/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要： Pyrimidine-4,6-dicarboxylic acid diamides of the formula I are suitable for selectively inhibiting collagenase (MMP 13). The pyrimidine-4,6-dicarboxylic acid diamides can therefore be used for treating degenerative joint diseases.
摘要翻译： 式I的嘧啶-4,6-二羧酸二酰胺适用于选择性抑制胶原酶（MMP 13）。 因此，嘧啶-4,6-二羧酸二酰胺可用于治疗退行性关节疾病。
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公开(公告)号：US08101595B2
公开(公告)日：2012-01-24
申请号：US12519570
申请日：2007-12-19
申请人： Ian Stansfield , Uwe Koch , Joerg Habermann , Frank Narjes
发明人： Ian Stansfield , Uwe Koch , Joerg Habermann , Frank Narjes
IPC分类号： C07D267/22 , A61K31/55 , A61P31/22
CPC分类号： C07D515/18 , C07D513/04 , C07D513/18
摘要： Compounds of the formula (I) wherein A, B, D, M, Ar, W, X, Y, Z and R1 are as defined herein, are useful in the prevention and treatment of hepatitis C infections. The compounds, their preparation, pharmaceutical compositions containing them and their use in medicine are disclosed.
摘要翻译： 其中A，B，D，M，Ar，W，X，Y，Z和R 1如本文所定义的式（I）化合物可用于预防和治疗丙型肝炎感染。 公开了化合物，其制备方法，含有它们的药物组合物及其在药物中的用途。
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公开(公告)号：US07781422B2
公开(公告)日：2010-08-24
申请号：US12004013
申请日：2007-12-19
申请人： Ian Stansfield , Uwe Koch , Joerg Habermann , Frank Narjes
发明人： Ian Stansfield , Uwe Koch , Joerg Habermann , Frank Narjes
IPC分类号： C07D267/22 , A61K31/55
CPC分类号： C07D285/00
摘要： Compounds of the formula (I): wherein A, B, D, M, Ar, W, X, Y, Z and R1 are as defined herein, are useful in the prevention and treatment of hepatitis C infections. The compounds, their preparation, pharmaceutical compositions containing them and their use in medicine are disclosed.
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公开(公告)号：US20080153895A1
公开(公告)日：2008-06-26
申请号：US12004013
申请日：2007-12-19
申请人： Ian Stansfield , Uwe Koch , Joerg Habermann , Frank Narjes
发明人： Ian Stansfield , Uwe Koch , Joerg Habermann , Frank Narjes
IPC分类号： A61K31/407 , C07D417/02 , A61P31/12
CPC分类号： C07D285/00
摘要： Compounds of the formula (I): wherein A, B, D, M, Ar, W, X, Y, Z and R1 are as defined herein, are useful in the prevention and treatment of hepatitis C infections. The compounds, their preparation, pharmaceutical compositions containing them and their use in medicine are disclosed.
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7.发明申请SUBSTITUED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权替代苯并呋喃化合物及其用于治疗病毒性疾病的方法公开(公告)号：US20150246902A1
公开(公告)日：2015-09-03
申请号：US14343462
申请日：2012-08-16
申请人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Qun Dang
发明人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Qun Dang
IPC分类号： C07D405/04 , C07D473/00 , A61K31/52 , A61K45/06 , A61K31/437 , C07D487/04 , A61K31/4985 , A61K31/5025 , A61K31/4184 , C07D471/04
CPC分类号： C07D405/04 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4985 , A61K31/5025 , A61K31/52 , A61K45/06 , C07D405/14 , C07D471/04 , C07D473/00 , C07D487/04 , C07D498/04 , Y02A50/387 , Y02A50/389 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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8.发明申请HETEROCYCLIC-SUBSTITUTED BENZOFURAN DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权杂环取代的苯唑嘌呤衍生物及其用于治疗病毒性疾病的方法公开(公告)号：US20140199263A1
公开(公告)日：2014-07-17
申请号：US14343448
申请日：2012-08-16
申请人： Casey Cameron McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Zhong Lai , Qun Dang , Nicolas Zorn
发明人： Casey Cameron McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Zhong Lai , Qun Dang , Nicolas Zorn
IPC分类号： C07D513/04 , A61K31/497 , C07D405/14 , A61K31/4439 , C07D413/14 , A61K31/4245 , A61K31/444 , A61K31/506 , C07D498/04 , C07D417/14 , A61K31/5377 , A61K31/501 , A61K31/433 , C07D409/14 , A61K31/5365 , A61K31/5383 , C07F7/10 , A61K31/695 , A61K45/06 , C07D471/04
CPC分类号： A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/695 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04 , C07D513/04 , C07F7/10 , Y02A50/385 , Y02A50/387 , Y02A50/389 , A61K31/424 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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公开(公告)号：US08232390B2
公开(公告)日：2012-07-31
申请号：US12299833
申请日：2007-05-04
申请人： Elena Capito , Joerg Habermann , Frank Narjes , Maria del Rosario Rico Ferreira , Ian Stansfield
发明人： Elena Capito , Joerg Habermann , Frank Narjes , Maria del Rosario Rico Ferreira , Ian Stansfield
IPC分类号： C07D225/04 , C07D267/22 , C07D223/14 , C07D267/02 , A61K31/55
CPC分类号： C07D487/04
摘要： The present invention relates to pentacyclic indole derivatives of formula (I): wherein A, Ar, R1, R2, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
摘要翻译： 本发明涉及式（I）的五环吲哚衍生物：其中A，Ar，R 1，R 2，W，X，Y和Z如本文所定义，及其药学上可接受的盐，包含它们的药物组合物及其用于 治疗或预防丙型肝炎病毒感染。
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公开(公告)号：US07973026B2
公开(公告)日：2011-07-05
申请号：US11920064
申请日：2006-05-03
申请人： Stefania Colarusso , Joerg Habermann , Frank Narjes , Simona Ponzi , Maria del Rosario Rico Ferreira
发明人： Stefania Colarusso , Joerg Habermann , Frank Narjes , Simona Ponzi , Maria del Rosario Rico Ferreira
IPC分类号： A61K31/33 , C07D487/00
CPC分类号： C07D495/14
摘要： The present invention relates to tetracyclic thienopyrrole compounds of formula (I), wherein Ar, A, D1, D2, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
摘要翻译： 本发明涉及式（I）的四环噻吩并吡咯化合物，其中Ar，A，D1，D2，W，X，Y和Z如本文所定义，及其药学上可接受的盐，包含它们的药物组合物及其用于 治疗或预防丙型肝炎病毒感染。
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