发明授权
- 专利标题： Amino acid sequence presenting fusion polypeptide and its use
- 专利标题（中）： 氨基酸序列呈现融合多肽及其用途
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申请号： US14112108申请日： 2012-05-04
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公开(公告)号： US09266962B2公开(公告)日： 2016-02-23
- 发明人: Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
- 申请人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
- 申请人地址： US NJ Nutley
- 专利权人： Hoffman-La Roche Inc.
- 当前专利权人： Hoffman-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理机构： Jones Day
- 国际申请： PCT/EP2012/058207 WO 20120504
- 国际公布： WO2012/150320 WO 20121108
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K16/40 ; C07K16/22 ; C12N9/90 ; C07K16/12 ; G01N33/74 ; G01N33/573
摘要：
Herein is reported a fusion polypeptide according to formula (I): NH2—S2—X1—S1—COOH, wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.