Invention Grant
- Patent Title: Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof
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Application No.: US14627573Application Date: 2015-02-20
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Publication No.: US09273014B2Publication Date: 2016-03-01
- Inventor: Ashvinikumar V. Gavai , George V. DeLucca , Daniel O'Malley , Patrice Gill , Claude A. Quesnelle , Brian E. Fink , Yufen Zhao , Francis Y. Lee
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K47/00 ; C07D243/24 ; A61K31/5513 ; A61K31/573 ; A61K31/675 ; A61K38/05 ; A61K45/06 ; C07D401/04 ; C07F9/645 ; C07K5/062 ; C07D243/18 ; C07D243/26 ; C07F9/12 ; A61K9/00 ; A61K9/08 ; A61K31/138 ; A61K31/337 ; A61K31/506 ; A61K31/555 ; C07F7/18 ; C07F9/38 ; A61K9/48 ; A61K47/48

Abstract:
Disclosed are compounds of Formula (I) and/or salts thereof: wherein R1 is —CH2CH2CF3; R2 is —CH2CH2CF3 or —CH2CH2CH2CF3; R3 is H, —CH3, or Rx; R4 is H or Ry; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer; or as prodrugs of such compounds.
Public/Granted literature
- US20150166489A1 BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AND PRODRUGS THEREOF Public/Granted day:2015-06-18
Information query
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