Invention Grant
US09290761B2 MicroRNA inhibition for the treatment of inflammation and myeloproliferative disorders
有权
用于治疗炎症和骨髓增生性疾病的微小RNA抑制剂
- Patent Title: MicroRNA inhibition for the treatment of inflammation and myeloproliferative disorders
- Patent Title (中): 用于治疗炎症和骨髓增生性疾病的微小RNA抑制剂
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Application No.: US14138472Application Date: 2013-12-23
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Publication No.: US09290761B2Publication Date: 2016-03-22
- Inventor: David Baltimore , Ryan M. O'Connell , Konstantin Taganov , Mark Boldin
- Applicant: California Institute of Technology
- Applicant Address: US CA Pasadena
- Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee Address: US CA Pasadena
- Agency: Knobbe Martens Olson & Bear LLP
- Main IPC: A01N43/04
- IPC: A01N43/04 ; C12Q1/68 ; C12N15/113 ; A61K31/56 ; A61K45/06
Abstract:
The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csflr, HIF1α, Sla, Cepbβ, and Bach1, and the like.
Public/Granted literature
- US20140220049A1 MICRORNA INHIBITION FOR THE TREATMENT OF INFLAMMATION AND MYELOPROLIFERATIVE DISORDERS Public/Granted day:2014-08-07
Information query
IPC分类:
