公开(公告)号：US09862948B2

公开(公告)日：2018-01-09

申请号：US15016096

申请日：2016-02-04

Applicant: California Institute of Technology

Inventor： David Baltimore ,  Ryan M. O'Connell ,  Konstantin Taganov ,  Mark Boldin

IPC: A01N43/04 ,  C12Q1/68 ,  C12N15/113 ,  A61K31/56 ,  A61K45/06 ,  A61K31/7105

CPC classification number: C12N15/113 ,  A61K31/56 ,  A61K31/7105 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/31

Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1α, Sla, Cebpβ, and Bach1, and the like.

公开(公告)号：US10435689B2

公开(公告)日：2019-10-08

申请号：US15831839

申请日：2017-12-05

Applicant: California Institute of Technology

Inventor： David Baltimore ,  Ryan M. O'Connell ,  Konstantin Taganov ,  Mark Boldin

IPC: A01N43/04 ,  C12Q1/68 ,  C12N15/113 ,  A61K31/56 ,  A61K45/06 ,  A61K31/7105

Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csf1r, HIF1α, Sla, Cepbβ, and Bach1, and the like.

公开(公告)号：US09290761B2

公开(公告)日：2016-03-22

申请号：US14138472

申请日：2013-12-23

Applicant: California Institute of Technology

Inventor： David Baltimore ,  Ryan M. O'Connell ,  Konstantin Taganov ,  Mark Boldin

IPC: A01N43/04 ,  C12Q1/68 ,  C12N15/113 ,  A61K31/56 ,  A61K45/06

CPC classification number: C12N15/113 ,  A61K31/56 ,  A61K31/7105 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/31

Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csflr, HIF1α, Sla, Cepbβ, and Bach1, and the like.

Abstract translation: 本公开涉及microRNA-155在炎症，造血和骨髓增生中起作用的发现，并且微小RNA-155表达的调节异常与特定的骨髓增生性疾病相关。 本文公开了用于诊断治疗疾病（包括炎症和骨髓增生）的方法和组合物，调节选自Cut1，Arnt1，Picalm，Jarid2，PU.1，Csflr，HIF1α，Sla的一种或多种基因的表达水平 ，Cepb＆bgr，和Bach1等。

公开(公告)号：US20180187193A1

公开(公告)日：2018-07-05

申请号：US15831839

申请日：2017-12-05

Applicant: California Institute of Technology

Inventor： David Baltimore ,  Ryan M. O'Connell ,  Konstantin Taganov ,  Mark Boldin

IPC: C12N15/113 ,  A61K31/56 ,  A61K31/7105 ,  A61K45/06

CPC classification number: C12N15/113 ,  A61K31/56 ,  A61K31/7105 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/31

Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csf1r, HIF1α, Sla, Cepbβ, and Bach1, and the like.

公开(公告)号：US20160244754A1

公开(公告)日：2016-08-25

申请号：US15016096

申请日：2016-02-04

Applicant: California Institute of Technology

Inventor： David Baltimore ,  Ryan M. O'Connell ,  Konstantin Taganov ,  Mark Boldin

IPC: C12N15/113 ,  A61K45/06 ,  A61K31/7105

CPC classification number: C12N15/113 ,  A61K31/56 ,  A61K31/7105 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/31

Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1α, Sla, Cepbβ, and Bach1, and the like.

Abstract translation: 本公开涉及microRNA-155在炎症，造血和骨髓增生中起作用的发现，并且微小RNA-155表达的调节异常与特定的骨髓增生性疾病相关。 本文公开了用于诊断治疗疾病（包括炎症和骨髓增生）的方法和组合物，调节选自Cutl1，Arnt1，Picalm，Jarid2，PU.1，Csf1r，HIF1α，Sla的一种或多种基因的表达水平 ，Cepbβ和Bach1等。

公开(公告)号：US20140220049A1

公开(公告)日：2014-08-07

申请号：US14138472

申请日：2013-12-23

Applicant: California Institute of Technology

Inventor： David Baltimore ,  Ryan M. O'Connell ,  Konstantin Taganov ,  Mark Boldin

IPC: C12N15/113 ,  A61K31/56 ,  A61K45/06

CPC classification number: C12N15/113 ,  A61K31/56 ,  A61K31/7105 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/31

Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csflr, HIFlα, Sla, Cepbβ, and Bach1, and the like.

Abstract translation: 本公开涉及microRNA-155在炎症，造血和骨髓增生中起作用的发现，并且微小RNA-155表达的调节异常与特定的骨髓增生性疾病相关。 本文公开了用于诊断治疗疾病（包括炎症和骨髓增生）的方法和组合物，调节选自Cutl1，Arnt1，Picalm，Jarid2，PU.1，Csflr，HIF1α，Sla的一种或多种基因的表达水平 ，Cepb＆bgr，和Bach1等。