发明授权
US09290781B2 Composition containing 2-acyl-lysophosphatidylserine and method for producing the same
有权
含有2-酰基 - 溶血磷脂酰丝氨酸的组合物及其制备方法
- 专利标题: Composition containing 2-acyl-lysophosphatidylserine and method for producing the same
- 专利标题(中): 含有2-酰基 - 溶血磷脂酰丝氨酸的组合物及其制备方法
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申请号: US13824518申请日: 2011-09-26
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公开(公告)号: US09290781B2公开(公告)日: 2016-03-22
- 发明人: Kazunaga Yazawa , Tomoyuki Susa , Shoji Gotoh , Yasuhito Tashiro , Junichi Kawashima , Shigeyuki Imamura
- 申请人: Kazunaga Yazawa , Tomoyuki Susa , Shoji Gotoh , Yasuhito Tashiro , Junichi Kawashima , Shigeyuki Imamura
- 申请人地址: JP Tokyo JP Tokyo
- 专利权人: National University Corporation Tokyo University of Marine Science and Technology,Meiji Co., Ltd.
- 当前专利权人: National University Corporation Tokyo University of Marine Science and Technology,Meiji Co., Ltd.
- 当前专利权人地址: JP Tokyo JP Tokyo
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2010-220880 20100930
- 国际申请: PCT/JP2011/071900 WO 20110926
- 国际公布: WO2012/043481 WO 20120405
- 主分类号: C12P13/06
- IPC分类号: C12P13/06 ; A61K31/685 ; C12P7/64
摘要:
The present invention provides a method for producing a composition containing 2-acyl-lysophosphatidylserine, including (a) a step of obtaining a composition containing phosphatidylserine by allowing phospholipase D to act on a raw material containing phosphatidylcholine in the presence of serine and (b) a step of obtaining a composition containing 2-acyl-lysophosphatidylserine by allowing phospholipase A1 to act on the composition containing phosphatidylserine in the presence of one or more additives selected from the group consisting of the following (I), (II), and (III), in which (I) one or more salts selected from the group consisting of sulfate salts, phosphate salts, nitrate salts, citrate salts, and tartarate salts of monovalent cations, (II) a gum, and (III) an emulsifier.
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