Invention Grant
- Patent Title: Combination therapy for proliferative disorders
- Patent Title (中): 联合治疗增生性疾病
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Application No.: US13313042Application Date: 2011-12-07
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Publication No.: US09295669B2Publication Date: 2016-03-29
- Inventor: Kapil Dhingra , Brian Higgins , Kenneth Kolinsky , Richard J. Lee , Brian Lestini , Kathryn Packman , Fei Su
- Applicant: Kapil Dhingra , Brian Higgins , Kenneth Kolinsky , Richard J. Lee , Brian Lestini , Kathryn Packman , Fei Su
- Applicant Address: US NJ Nutley
- Assignee: Hoffman La-Roche Inc.
- Current Assignee: Hoffman La-Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agency: Morrison & Foerster LLP
- Main IPC: A61K31/535
- IPC: A61K31/535 ; A61K31/505 ; A61K38/21 ; A01N43/54 ; A01N43/42 ; C07D413/00 ; C07D239/02 ; C07D401/00 ; C07D403/00 ; C07D471/02 ; A61K31/437
Abstract:
The present invention relates to a combination therapy of propane-1-sulfonic acid{3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluoro-phenyl]-amide}, or a pharmaceutically acceptable salt thereof, and an interferon for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. In particular, the present invention relates to such a therapy wherein the interferon is peginterferon alfa-2a and the disorder is melanoma containing the V600E b-Raf mutation.
Public/Granted literature
- US20120148533A1 COMBINATION THERAPY Public/Granted day:2012-06-14
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