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    Method for cancer therapy
    3.
    发明授权
    Method for cancer therapy 有权

    公开(公告)号：US06548531B2

    公开(公告)日：2003-04-15

    申请号：US10055451

    申请日：2002-01-23

    申请人： Lars Holger Breimer ,  Kapil Dhingra ,  Urvashi Hooda Dhingra ,  Steve Ritland

    发明人： Lars Holger Breimer ,  Kapil Dhingra ,  Urvashi Hooda Dhingra ,  Steve Ritland

    IPC分类号： A61R31405

    CPC分类号： A61K31/337 ,  A61K31/404 ,  A61K31/40 ,  A61K31/335 ,  A61K2300/00

    摘要： Disclosed is a method of treating a patient suffering from cancer. The method comprises administering to a patient over a period of up to about 15 days a first component and a second component. The first component consists of a pharmaceutical composition containing as an active ingredient a compound of formula I or a pharmaceutically acceptable salt or ester of said compound. The second component consists of an injection solution containing as an active ingredient paclitaxel. The amount of each component in the combination is such that the combination is therapeutically effective. The components are administered concomitantly or sequentially in a three week to four week treatment cycle for as long as the tumor remains under control and the patient tolerates the regimen.

    COMBINATION THERAPY
    5.
    发明申请
    COMBINATION THERAPY 有权
    组合治疗

    公开(公告)号：US20120148533A1

    公开(公告)日：2012-06-14

    申请号：US13313042

    申请日：2011-12-07

    申请人： Kapil Dhingra ,  Brian Higgins ,  Kenneth Kolinsky ,  Richard J. Lee ,  Brian Lestini ,  Kathryn Packman ,  Fei Su

    发明人： Kapil Dhingra ,  Brian Higgins ,  Kenneth Kolinsky ,  Richard J. Lee ,  Brian Lestini ,  Kathryn Packman ,  Fei Su

    IPC分类号： A61K38/21 ,  A61P35/00

    CPC分类号： A61K38/212 ,  A61K31/437 ,  A61K38/21 ,  A61K2300/00

    摘要： The present invention relates to a combination therapy of propane-1-sulfonic acid{3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluoro-phenyl]-amide}, or a pharmaceutically acceptable salt thereof, and an interferon for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. In particular, the present invention relates to such a therapy wherein the interferon is peginterferon alfa-2a and the disorder is melanoma containing the V600E b-Raf mutation.

    摘要翻译： 本发明涉及丙烷-1-磺酸{3- [5-（4-氯 - 苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基-2,4-二氟 - 苯基] - 酰胺}或其药学上可接受的盐，以及用于治疗患有增殖性疾病，特别是实体瘤例如结肠直肠癌，黑素瘤和甲状腺癌的患者的干扰素。 特别地，本发明涉及这样的治疗，其中干扰素是聚乙二醇化干扰素α-2a，该病症是含有V600E b-Raf突变的黑素瘤。