Invention Grant
US09296776B2 Substituted nucleoside derivatives with antiviral and antimicrobial properties
有权
取代的具有抗病毒和抗微生物特性的核苷衍生物
- Patent Title: Substituted nucleoside derivatives with antiviral and antimicrobial properties
- Patent Title (中): 取代的具有抗病毒和抗微生物特性的核苷衍生物
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Application No.: US12668262Application Date: 2008-07-09
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Publication No.: US09296776B2Publication Date: 2016-03-29
- Inventor: Gustavo F. Doncel , Keykavous Parang , Hitesh Kumar Agarwal
- Applicant: Gustavo F. Doncel , Keykavous Parang , Hitesh Kumar Agarwal
- Applicant Address: US VA Norfolk US RI Providence
- Assignee: Eastern Virginia Medical School,Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
- Current Assignee: Eastern Virginia Medical School,Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
- Current Assignee Address: US VA Norfolk US RI Providence
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- International Application: PCT/US2008/069571 WO 20080709
- International Announcement: WO2009/009625 WO 20090115
- Main IPC: C07H19/06
- IPC: C07H19/06 ; C07H19/10 ; C07H19/16 ; C07H19/20
Abstract:
The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.
Public/Granted literature
- US20110039798A1 SUBSTITUTED NUCLEOSIDE DERIVATIVES WITH ANTIVIRAL AND ANTIMICROBIAL PROPERTIES Public/Granted day:2011-02-17
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