发明授权
- 专利标题： Sustained-release pharmaceutical composition
- 专利标题（中）： 持续释放药物组合物
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申请号： US13824598申请日： 2011-10-14
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公开(公告)号： US09301917B2公开(公告)日： 2016-04-05
- 发明人: Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
- 申请人： Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
- 申请人地址： JP Kyoto JP Kyoto JP Tokyo JP Tokyo
- 专利权人： Kyoto University,Kyoto Prefectural Public University Corporation,Kaken Pharmaceutical Co., Ltd.,Koken Co., Ltd.
- 当前专利权人： Kyoto University,Kyoto Prefectural Public University Corporation,Kaken Pharmaceutical Co., Ltd.,Koken Co., Ltd.
- 当前专利权人地址： JP Kyoto JP Kyoto JP Tokyo JP Tokyo
- 代理机构： Kilyk & Bowersox, P.L.L.C.
- 优先权： JP2010-232113 20101015
- 国际申请： PCT/JP2011/073632 WO 20111014
- 国际公布： WO2012/050184 WO 20120419
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K9/00 ; A61K31/7004 ; A61K31/7008 ; A61K45/06 ; A61K38/39 ; A61K9/51 ; A61K47/26 ; A61K47/42 ; A61K38/27 ; A61K38/18
摘要：
Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.
公开/授权文献
- US20130225492A1 Sustained-Release Pharmaceutical Composition 公开/授权日：2013-08-29
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