Protocol adaptation layer for wireless communications. Communication devices that include one or more radio modules operable in accordance with multiple communication protocols establish communications using one communication protocol and then switch to another communication protocol. This switching to another communication protocol may be performed based on a variety of factors including effectuating communications of higher throughput, supporting uni-directional communications vs. bi-directional communications, or any other desired factor. In some embodiments, various communication devices include two radio modules that are each implemented to operate in accordance with one particular communication protocol. Alternatively, a multi-protocol capable radio module may support and operate in accordance with more than one communication protocol. Examples of possible communication protocols include those compliant with Bluetooth, IEEE 802.11, and/or 802.15.3c.