发明授权
- 专利标题： Adsorption of immunopotentiators to insoluble metal salts
- 专利标题（中）： 免疫增强剂对不溶性金属盐的吸附
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申请号： US13820370申请日： 2011-09-01
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公开(公告)号： US09315530B2公开(公告)日： 2016-04-19
- 发明人: Manmohan Singh , David A. G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
- 申请人： Manmohan Singh , David A. G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理商 Helen Lee; Virginia Campen
- 国际申请： PCT/US2011/050231 WO 20110901
- 国际公布： WO2012/031140 WO 20120308
- 主分类号： A61K39/39
- IPC分类号： A61K39/39 ; C07F9/6561 ; A61K31/661 ; A61K31/6615 ; A61K31/662 ; A61K39/095 ; C07D471/04 ; C07D487/04 ; C07F9/645 ; C07F9/6512 ; C07F9/6558 ; A61K39/00
摘要：
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
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