发明授权
- 专利标题： Anti-AXL antibody
- 专利标题（中）： 抗AXL抗体
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申请号： US13320317申请日： 2010-05-14
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公开(公告)号： US09340615B2公开(公告)日： 2016-05-17
- 发明人: Atsuhiko Maeda , Hajime Miyamoto , Taichi Kuramochi , Atsushi Matsuo , Tomoyuki Igawa , Hirotake Shiraiwa , Hiroyuki Tsunoda , Tatsuhiko Tachibana
- 申请人： Atsuhiko Maeda , Hajime Miyamoto , Taichi Kuramochi , Atsushi Matsuo , Tomoyuki Igawa , Hirotake Shiraiwa , Hiroyuki Tsunoda , Tatsuhiko Tachibana
- 申请人地址： JP Tokyo
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo
- 代理机构： Fish & Richardson P.C.
- 优先权： JP2009-118725 20090515
- 国际申请： PCT/JP2010/058166 WO 20100514
- 国际公布： WO2010/131733 WO 20101118
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K16/28 ; C07K16/30 ; A61K39/00
摘要：
An objective of the present invention is to decrease the immunogenicity of mouse-derived anti-AXL antibodies in humans by humanizing them. The present invention provides antibodies that can bind to a specific region in Anexelekto (AXL) and humanized antibodies that are produced based on such antibodies. The anti-AXL antibodies of the present invention have high antitumor activity, and are useful as agents for decreasing the AXL expression level, antitumor agents, and diagnostic agents for cancer.
公开/授权文献
- US20120121587A1 ANTI-AXL ANTIBODY 公开/授权日：2012-05-17