A hybrid memory system. This system can include a processor coupled to a hybrid memory buffer (HMB) that is coupled to a plurality of DRAM and a plurality of Flash memory modules. The HMB module can include a Memory Storage Controller (MSC) module and a Near-Memory-Processing (NMP) module coupled by a SerDes (Serializer/Deserializer) interface. This system can utilize a hybrid (mixed-memory type) memory system architecture suitable for supporting low-latency DRAM devices and low-cost NAND flash devices within the same memory sub-system for an industry-standard computer system.