A high-frequency spindle has a tube shaft extending along and rotatable about an axis, a chuck carried on a front end of the shaft, adapted to fit with a tool or tool holder, and a ball cage in the shaft and having a radially extending window. A locking ball os radially displaceable in the window between a holding position engaging in a seat of the tool and a freeing position clear of the seat. An angled surface is engageable radially with the ball, and an actuating rod is axially shiftable and coupled to the cage or to the angled surface. An actuator can axially shift the rod and thereby relatively axially displace the ball and the angled surface and cam the ball with the angled surface into the holding position. A primary spring biases the rod so as shift the ball with the angled surface into the holding position.