发明授权
US09360472B2 Cell line, system and method for optical-based screening of ion-channel modulators
有权
用于离子通道调节剂的光学筛选的细胞系，系统和方法
- 专利标题： Cell line, system and method for optical-based screening of ion-channel modulators
- 专利标题（中）： 用于离子通道调节剂的光学筛选的细胞系，系统和方法
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申请号： US13850436申请日： 2013-03-26
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公开(公告)号： US09360472B2公开(公告)日： 2016-06-07
- 发明人: Karl Deisseroth , Feng Zhang , Viviana Gradinaru , M. Bret Schneider
- 申请人： The Board of Trustees of the Leland Stanford Junior University
- 申请人地址： US CA Stanford
- 专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： US CA Stanford
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 Paula A. Borden
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61N5/06 ; C40B60/12 ; G01N33/68
摘要：
A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor.