Invention Grant
- Patent Title: Pyridine and pyrazine derivative for the treatment of CF
-
Application No.: US14521843Application Date: 2014-10-23
-
Publication No.: US09365552B2Publication Date: 2016-06-14
- Inventor: Urs Baettig , Kamlesh Bala , Emma Budd , Lee Edwards , Catherine Howsham , Glyn Alan Hughes , Darren Mark Legrand , Katrin Spiegel
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Laura K. Madden
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/443 ; A61K31/4439 ; A61K31/444 ; A61K31/4545 ; A61K31/4965 ; A61K31/497 ; A61K31/5377 ; A61K31/4418 ; A61K45/06 ; C07D405/04 ; C07D213/81 ; C07D241/28 ; C07D401/04 ; C07D405/12 ; C07D413/04 ; C07D413/12 ; C07D213/38 ; C07D401/12 ; C07D403/12 ; A61K31/4412
Abstract:
The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
Public/Granted literature
- US20150045364A1 Pyridine and Pyrazine derivative for the Treatment of CF Public/Granted day:2015-02-12
Information query
