Invention Grant
- Patent Title: Genetically modified muscle cells which express neurotrophic factors
- Patent Title (中): 表达神经营养因子的转基因细胞
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Application No.: US14002782Application Date: 2012-03-01
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Publication No.: US09365828B2Publication Date: 2016-06-14
- Inventor: Daniel Offen , Michal Dadon-Nachum , Tali Ben-Zur , Eldad Melamed , David Yaffe
- Applicant: Daniel Offen , Michal Dadon-Nachum , Tali Ben-Zur , Eldad Melamed , David Yaffe
- Applicant Address: IL Tel-Aviv IL Rehovot
- Assignee: Ramot at Tel-Aviv University Ltd.,Yeda Research and Development Co., Ltd.
- Current Assignee: Ramot at Tel-Aviv University Ltd.,Yeda Research and Development Co., Ltd.
- Current Assignee Address: IL Tel-Aviv IL Rehovot
- International Application: PCT/IB2012/050976 WO 20120301
- International Announcement: WO2012/117373 WO 20120907
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K48/00 ; C12N5/077 ; A61K35/34 ; A61K35/12 ; A61K38/00
Abstract:
An isolated muscle progenitor cell being MyoD positive, CD34 negative and CD45 negative is disclosed. The muscle progenitor cell is genetically modified to express at least one neurotrophic factor. In addition, cell populations are disclosed, comprising at least four subpopulations of muscle cells each being genetically modified to express a different neurotrophic factor, wherein said neurotrophic factor is selected from the group consisting of glial derived neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). Uses of the cell populations are also disclosed.
Public/Granted literature
- US20130344041A1 GENETICALLY MODIFIED MUSCLE CELLS WHICH EXPRESS NEUROTROPHIC FACTORS Public/Granted day:2013-12-26
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