Invention Grant
- Patent Title: Processes of making and crystalline forms of a MDM2 inhibitor
- Patent Title (中): MDM2抑制剂的制备方法和结晶形式
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Application No.: US14301087Application Date: 2014-06-10
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Publication No.: US09376386B2Publication Date: 2016-06-28
- Inventor: Matthew Bio , Sebastien Caille , Brian Cochran , Yuanqing Fang , Filisaty Vounatsos , Sarah Wortman
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen, Inc.
- Current Assignee: Amgen, Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Joseph W. Bulock; Elsa D. Lemoine; Markus Bergauer
- Main IPC: C07D211/94
- IPC: C07D211/94 ; C07D491/048 ; C07C309/25 ; C07C309/04 ; C07D498/04 ; C07D211/76 ; C07C309/35
Abstract:
The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Public/Granted literature
- US20140364455A1 PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR Public/Granted day:2014-12-11
Information query
