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发明授权
US09376468B2 Cell penetrating peptides for intracellular delivery of molecules 有权
细胞穿透肽用于分子的细胞内递送

Cell penetrating peptides for intracellular delivery of molecules
摘要：
The présent invention relates to cell-penetrating peptides char-acterized in that it comprises an amino acid séquence selected in the group consisting of X1LX2RALWX9LX3X9X4LWX9LX5X6X7X8, X1LX2LARWX9LX3X9X4LWX9LX5X6X7X8 and X1LX2ARLWX9LX3X9X4LWX9LX5X6X7X8, wherein X1 is beta-A or S, X2 is F or W, X3 is L, W, C or I, X4 is S, A, N or T, Xs is L or W, X6 is W or R, X7 is K or R, X8 is A or none, and X9 is R or S. Thèse peptides exhibit high efficiency, low toxicity and a natural tropism for lung tissues, and can be used either in simple complex with the cargo to be vectorised, or in nanoparticles comprising two layers of cell-penetrating peptides around the cargo.
摘要（中）：

本发明涉及细胞穿透肽，其特征在于其包含在由X1LX2RALWX9LX3X9X4LWX9LX5X6X7X8，X1LX2LARWX9XXXXXXXXXXXXLLX5X6X7X8和X1LX2ARLWX9LX3X9X4LWX9LX5X6X7X8组成的组中选择的氨基酸选择性，其中X1为β-A或S，X2为F或W，X3为L ，W，C或I，X4为S，A，N或T，X为L或W，X6为W或R，X7为K或R，X8为A或无，X9为R或S. 表现出高效率，低毒性和肺组织的自然向性，并且可以与要载体的货物的简单复合物或者包含在货物周围的两层细胞穿透肽的纳米颗粒中使用。

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