发明授权
- 专利标题: Integration of meningococcal conjugate vaccination
- 专利标题(中): 脑膜炎球菌结合疫苗的整合
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申请号: US11587170申请日: 2005-04-29
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公开(公告)号: US09402915B2公开(公告)日: 2016-08-02
- 发明人: Cameron John Marshall
- 申请人: Cameron John Marshall
- 申请人地址: BE Rixensart
- 专利权人: GlaxoSmithKline Biologicals SA
- 当前专利权人: GlaxoSmithKline Biologicals SA
- 当前专利权人地址: BE Rixensart
- 代理机构: Morrison & Foerster LLP
- 优先权: GB0409750.7 20040430; GB0500787.7 20050114
- 国际申请: PCT/GB2005/001653 WO 20050429
- 国际公布: WO2005/105140 WO 20051110
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; A61K39/00 ; A61K39/385 ; A61K39/095
摘要:
Conjugated meningococcal capsular saccharides will be introduced into immunization schedules in the near future, but the phenomenon of “carrier suppression” must first be addressed, particularly where multiple conjugates are to be used. It has been found that diphtheria toxoid and its derivatives (such as CRM197) can safely be used as the carrier protein, even where multiple meningococcal conjugates are administered at the same time and where a patient has previously been exposed to the carrier protein, either in the form of a previous immunogen (e.g. in a DTP vaccine) or as a previous carrier protein (e.g. in a Hib or pneumococcal conjugate vaccine). The invention provides a method for immunizing a patient, comprising administering multiple conjugates of meningococcal capsular saccharides, wherein each conjugate comprises a diphtheria toxoid (or derivative thereof) carrier protein, and the capsular saccharide, and wherein the patient has been pre-immunized with a diphtheria toxoid (or derivative thereof).
公开/授权文献
- US20090060945A1 Integration of meningococcal conjugate vaccination 公开/授权日:2009-03-05
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