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公开(公告)号：US20230116636A1
公开(公告)日：2023-04-13
申请号：US18080101
申请日：2022-12-13
IPC分类号： A61K31/7088 , A61K39/00 , A61K39/12
摘要： RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.
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公开(公告)号：US20230114607A1
公开(公告)日：2023-04-13
申请号：US18065089
申请日：2022-12-13
IPC分类号： A61K31/7088 , A61K39/00 , A61K39/12
摘要： RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.
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公开(公告)号：US11591364B2
公开(公告)日：2023-02-28
申请号：US16768402
申请日：2018-11-30
发明人： Ahmad Taimour Baig , Felicie Georgette Colette Denet , Juan Jose Diaz Garcia , Chad Austin Farrenburg , Lora Lea Lawrence , Kent Raymond Myers , Jeri Kay Sandvick , Jeb Yeatts Vandenburg
摘要： Saponin extracts containing at least 93% QS-21 main peak and 0.25-3% 2018 component by UV absorbance at 214 nm, methods for making said extracts, their use as vaccine adjuvants and related aspects.
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公开(公告)号：US11571472B2
公开(公告)日：2023-02-07
申请号：US15318490
申请日：2015-06-12
IPC分类号： A61K39/155 , A61K39/235 , A61K39/12 , A61K39/00
摘要： Immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic component containing a nucleic acid encoding an antigen of the same respiratory pathogen, wherein the immunogenic components are formulated for concurrent administration are provided, as well as methods for making and for administering such immunogenic combinations to elicit an immune response specific for the respiratory pathogen.
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公开(公告)号：US20220387614A1
公开(公告)日：2022-12-08
申请号：US17773637
申请日：2020-11-19
IPC分类号： A61K47/64 , A61K39/112 , A61K39/09
摘要： The present invention provides a glycoconjugate for administration to a subject in a method comprising the steps of: (i) administering a first dose of glycoconjugate; (ii) subsequently administering a second dose of glycoconjugate; wherein the amount of glycoconjugate in the first dose or first and second doses are atypically low, and also related aspects.
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公开(公告)号：US20220323354A1
公开(公告)日：2022-10-13
申请号：US17848294
申请日：2022-06-23
发明人： Andrew Geall
IPC分类号： A61K9/127 , A61K39/12 , C12N15/86 , A61K31/7088 , A61K39/00
摘要： Vaccines for eliciting an immune response are provided. The vaccines include lipid nanoparticles comprising lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These lipid nanoparticles can have essentially neutral surface charge at physiological pH and are effective for immunization.
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公开(公告)号：US20220305120A1
公开(公告)日：2022-09-29
申请号：US17618283
申请日：2020-06-09
摘要： Simian adenoviral vectors are formulated with bioadhesives and excipients that maintain immunogenicity. They can be administered mucosally to provide effective prophylaxis and therapy.
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公开(公告)号：US20220288190A1
公开(公告)日：2022-09-15
申请号：US17632270
申请日：2020-08-03
发明人： Pierre SAE HOUER , Pedro SANTANA DOS SANTOS , Laurent Bernard Jean STRODIOT , Bram VUYLSTEKE , Arnaud ZULIANI
IPC分类号： A61K39/145 , A61K47/26 , A61K47/10 , A61K39/07 , A61K39/104 , A61K47/02
摘要： The present invention relates to a process for preparing immunogenic compositions. More particularly, it relates to a process for preparing liquid compositions of Protein D polypeptide and their use in preparing immunogenic compositions comprising Protein D polypeptide which may be used in the treatment or prevention of an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a subject, e.g. human.
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公开(公告)号：US20220275397A1
公开(公告)日：2022-09-01
申请号：US17742221
申请日：2022-05-11
摘要： The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.
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公开(公告)号：US20220257751A1
公开(公告)日：2022-08-18
申请号：US17628667
申请日：2020-07-21
发明人： Massimilliano BIAGINI , Lucia Eleonora FONTANA , Anna GALEA , Nathalie NORAIS , Maria SCARSELLI
IPC分类号： A61K39/385 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/31 , C07K14/33 , C12P21/00 , C12Q1/37 , G01N33/68
摘要： The present invention provides analytical tools for the characterisation of bioconjugates, in particular for the measurement of glycosylation levels, and methods for absolute quantification of glycosylation sequences, as well as sequences and glycosylation sites for use in such methods.
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